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This has caused crises in countries bordering Venezuela, including Brazil. While di cult to know exactly how many Venezuelan citizens are currently in Brazil, more than , Venezuelans crossed the border between January and June , with more than half eventually returning to Venezuela. The municipal government of Boa Vista, the largest and capital city of Roraima, estimated in February that anywhere from 25, to 40, Venezuelans were living there making up about 7. By the time I rst arrived in Boa Vista to start research for a post-doctoral project, this in ux had led to rising tension between residents of Roraima and Venezuelan migrants. On the day I arrived in mid-August, a well-known member of the community in the border town of Pacaraima was beaten and robbed by assailants who appeared to be Venezuelan. In response, local residents attacked Venezuelan refugees in the area, burning their belongings and causing them to ee back across the border.

Other migrants opted to return to Venezuela for their own safety.

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The Brazilian border state of Roraima. Credit: Wikimedia Commons Amid this tension, politicians escalated their rhetoric, calling for drastic measures such as capping immigration from Venezuela and closing the border.

When the federal government refused to pursue harsher measures against Venezuelans, a sitting senator from Roraima who narrowly lost his bid for re- election this year resigned his position as leader of the government in the Senate.

Yet there are several reasons why this crisis is unlikely to spiral into a bona de regional crisis between the Brazilian and Venezuelan governments.

Already vulnerable to blackouts, a squabble with the Venezuelan government could be devastating to Roraima. This is not an issue where the state government would be interested in playing hardball.

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Second, the appeals from politicians had two other goals: spurring the federal government into action and winning votes. The state is heavily dependent on the federal government and does not have the resources to cope with this in ux of refugees alone.

Additionally, traditional politicians had an opportunity to de ect attention from their own mismanagement of public services by blaming health and education problems on Venezuelan migrants. At the same time, a wave of right-wing populism is gaining hold in the state. Yet realistic proposals are few and far between. Then, with the aid of a checkpoint inhibitor, the T-cell army is primed to take down that tumor as well as other tumors lurking throughout the body.

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Thus many small firms are racing to develop and test the first small-molecule STING agonists that could be injected systemically or taken via pill. Likewise, scientists recently discovered that radiation and chemotherapy may activate STING, thanks to the flotsam of DNA spilled from dying cancer cells. Mitchison wanted to use the money to study an anticancer compound called DMXAA that worked fantastically in mice but had just fallen flat in two Novartis-sponsored Phase III clinical trials.

Neither did she. Li had explained why the Novartis trials were unsuccessful. The Aduro team also gave the mice injections of tumor cells, which spread and covered their lungs.

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Astoundingly, injecting CDNs at one tumor activated T cells throughout the body, causing them to attack and clear cancer in other locations, including the tumor-riddled lungs Cell Rep.

Even though Li was the first to publish the structure, she was not able to patent it because Aduro had already done so.

Just months later, in March , Novartis announced that it would help Aduro develop and commercialize its preclinical STING agonist program for cancer immunotherapy.

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